"The Creeping Death"

So, I have this recurring problem where my 2007 Mac Pro (6gbRAM, 250gb HD, OS 10.6.8) freezes up app by app. The first sign is usually that my (ethernet) network traffic drops to zero (I have Intego Virusbarrier installed, which gives me an in/out traffic monitor in the menu bar) - this though my laptop will be maintaining a connection (either by ethernet or wireless) at the same time. It therefore sems likely that something on the Mac Pro is freezing up and killing the connection rather than the problem being with the router or modem.
Soon after, applications start to become unresponsive - as I click on each one I'll get a few seconds of responsiveness followed by spinning pizza until finally the OS goes and I have no choice but to hard shut-down by holding down the power key.
Sometimes I can force quit a couple of apps before everything freezes. Occasionally I can still access menus but nothing happens when I select items from them. Quite commonly the Finder will freeze, I'll be able to use force quit on it, but it won't come back; shortly thereafter I'll lose the menu bar and then I've had it.
I've had occasional instances of this since first buying the machine (1 per month or less?) but a couple of weeks ago it got really bad (Mac Pro would freeze within minutes of restart). I restarted in safe boot and got rid of a whole load of startup items - I'm now only running Intego Antivirus 6, StuffIt and DropBox. Things were stable after that but then I tried installing Google Drive and now I'm getting 2-3 freezes a day (usually after a couple of hours use). I've already uninstalled Google Drive but still having problems, so wondering if that was a coincidence...
I've been running Diskwarrior 4.3 after each freeze and each time I get a warning there were errors in the disk catalogue (presumably from the hard shut-down?)
Any thoughts welcome...

SYSTEM LOG
Jun 17 23:58:47 Whizzer WebProcess[233]: QUERY-HANG-DETECTED - time: 3.304618, DB size: 51791872
Jun 17 23:58:54 Whizzer Safari[218]: CFPropertyListCreateFromXMLData(): Old-style plist parser: missing semicolon in dictionary.
Jun 17 23:59:00: --- last message repeated 2 times ---
Jun 17 23:59:00 Whizzer kextloadlogger[249]: /Library/Rapport/bin/gakl_driver.kext
Jun 17 23:59:22 Whizzer /Applications/Safari.app/Contents/MacOS/Safari[218]: CGSKeyTranslateInitialize: KLGetCurrentKeyboardLayout or KLGetKeyboardLayoutProperty is not available, fall back to USA keymap
Jun 18 00:00:00 Whizzer Mail[264]: WARNING: multiple tasks with UID: T4931705
(Followed by 15 similar messages with different UID numbers)
Jun 18 00:00:01 Whizzer Mail[264]: WARNING: multiple tasks with UID: E42E216A-6EC9-4517-B408-B86BC14BD378
Jun 18 00:00:01 Whizzer Mail[264]: Trying to add a To Do UID (E42E216A-6EC9-4517-B408-B86BC14BD378) that already exists in the cache and for the same mailbox. Perhaps this should have been an update. Skipping to avoid cyclic reconciliation.
(Followed by 31 similar messages with different UID numbers)
Jun 18 00:00:01 Whizzer Mail[264]: WARNING: multiple tasks with UID: T4931705
(Followed by 15 similar messages with different UID numbers)
Jun 18 00:03:35 Whizzer Mail[264]: GET /internetservices/issupport/2_27a4cv2b6061/clientConfig.plist (FAILED), httpStatusCode:-1, errorType:106 (domain=AYErrorDomain, code=2), transactionState:5, txnId:A9E4F7C1-ED03-4B32-95F7-968976A56A26, auto-retries=0, manual-retries=0
Jun 18 00:06:35 Whizzer Mail[264]: GET /Library/Application Support/Mail/Alias.xml (FAILED), httpStatusCode:-1, errorType:106 (domain=AYErrorDomain, code=2), transactionState:5, txnId:B27A866E-FE8C-42DC-A088-3A5203307118, auto-retries=0, manual-retries=0
Jun 18 00:07:28 Whizzer /System/Library/CoreServices/CCacheServer.app/Contents/MacOS/CCacheServer[198]: No valid tickets, timing out
Jun 18 00:20:39 Whizzer configd[14]: PMConnection mDNSResponder com.apple.powermanagement.applicationresponse.timedout 25000 ms
(I put the machine to sleep without realizing there's a problem: 40 minutes later I wake it up in order to shut down:)
Jun 18 01:04:18 Whizzer configd[14]: Sleep: Success - AC - Idle Sleep
Jun 18 01:04:18 Whizzer configd[14]: Wake: Success - AC - UHC3
Jun 18 01:04:18 Whizzer configd[14]: Hibernate Statistics
Jun 18 01:04:18 Whizzer configd[14]: Kernel loginwindow com.apple.powermanagement.applicationresponse.timedout 30000 ms
Jun 18 01:04:18 Whizzer configd[14]: Kernel Finder com.apple.powermanagement.applicationresponse.timedout 30000 ms
Jun 18 01:04:18 Whizzer configd[14]: Kernel configd com.apple.powermanagement.applicationresponse.slowresponse 25006 ms
Jun 18 01:04:37 Whizzer configd[14]: PMConnection AirPort configd plug-in com.apple.powermanagement.applicationresponse.timedout 25000 ms
Jun 18 01:04:37 Whizzer configd[14]: PMConnection mDNSResponder com.apple.powermanagement.applicationresponse.timedout 25000 ms
Jun 18 01:04:37 Whizzer configd[14]: PMConnection IPConfiguration com.apple.powermanagement.applicationresponse.timedout 25000 ms
Jun 18 10:50:52 localhost com.apple.launchd[1]: *** launchd[1] has started up. ***
Jun 18 10:50:59 localhost com.apple.launchd[1] (com.bombich.ccc.scheduledtask.5D6D9EEC-381D-4ED1-87FA-3A49FBCCE46A): Unknown key for dictionary: cccTaskDict
Jun 18 10:50:59 localhost DirectoryService[11]: Improper shutdown detected
Jun 18 10:51:00 localhost blued[17]: Apple Bluetooth daemon started
Jun 18 10:51:08 localhost mDNSResponder[18]: mDNSResponder mDNSResponder-258.21 (May 26 2011 14:40:13) starting
Jun 18 10:51:09 localhost mDNSResponder[18]: Adding registration domain XXXXXX.
Jun 18 10:51:09 localhost configd[14]: Sleep - Filtered Sleep Failure Report - Power Button Shutdown - Apps Failure
Jun 18 10:51:09 localhost configd[14]: bootp_session_transmit: bpf_write(en2) failed: Network is down (50)
Jun 18 10:51:09 localhost configd[14]: DHCP en2: INIT transmit failed
Jun 18 10:51:09 localhost blued[17]: writeExtendedInquiryResponse returned 144
Jun 18 10:51:09 localhost blued[17]: writeExtendedInquiryResponse returned 228
Jun 18 10:51:09 localhost configd[14]: network configuration changed.
Jun 18 10:51:09 Whizzer configd[14]: setting hostname to "Whizzer.local"
Jun 18 10:51:11 Whizzer configd[14]: network configuration changed.
Jun 18 10:51:11 Whizzer awacsd[40]: Starting awacsd connectivity-35.3 (May 26 2011 14:39:20)
Jun 18 10:51:11 Whizzer awacsd[40]: Connecting AWACS client: matt_brooker hello.connectivity.me.com
Jun 18 10:51:12 Whizzer bootlog[65]: BOOT_TIME: 1340013049 0
KERNEL LOG
Jun 17 23:55:59 Whizzer kernel[0]: USBF:          13.554          AppleUSBUHCI[0xaf6d000]::Found a transaction which hasn't moved in 5 seconds on bus 0x5d, timing out! (Addr: 2, EP: 0)
Jun 17 23:55:59 Whizzer kernel[0]: [0bbbc400][BNBMouseDevice::init][54] init is complete
Jun 17 23:55:59 Whizzer kernel[0]: [0bbbc400][BNBMouseDevice::handleStart][54] Done
Jun 17 23:55:59 Whizzer kernel[0]: [0bbce300][AppleMultitouchHIDEventDriver::start] entered
Jun 17 23:56:00 Whizzer kernel[0]: [0b6b5380][AppleMultitouchDevice::start] entered
Jun 17 23:56:12 Whizzer kernel[0]: utun_ctl_connect: creating interface utun0
Jun 18 00:20:15 Whizzer kernel[0]: PM notification timeout (pid 44, loginwindow)
Jun 18 00:20:39: --- last message repeated 3 times ---
Jun 18 00:20:15 Whizzer kernel[0]: PM notification timeout (pid 164, Finder)
Jun 18 00:20:45 Whizzer kernel[0]: PM notification timeout (pid 44, loginwindow)
Jun 18 00:20:45: --- last message repeated 3 times ---
Jun 18 00:20:45 Whizzer kernel[0]: PM notification timeout (pid 164, Finder)
Jun 18 00:20:46 Whizzer kernel[0]: System Sleep
Jun 18 01:04:12 Whizzer kernel[0]: Wake reason = UHC3
Jun 18 01:04:12 Whizzer kernel[0]: System Wake
Jun 18 01:04:12 Whizzer kernel[0]: The USB device WirelessControllerDevice (Port 2 of Hub at 0x5d000000) may have caused a wake by issuing a remote wakeup (2)
Jun 18 01:04:12 Whizzer kernel[0]: EIR is not supported.
Jun 18 01:04:14 Whizzer kernel[0]: Ethernet [Intel8254x]: Link up on en1, 100-Megabit, Full-duplex, Symmetric flow-control, Debug [792d,6f08,0de1,0e00,45e1,4000]
Jun 18 01:06:42 Whizzer kernel[0]: Ethernet [Intel8254X]: Link down on en1
Jun 18 01:06:52 Whizzer kernel[0]: Ethernet [Intel8254x]: Link up on en1, 100-Megabit, Full-duplex, Symmetric flow-control, Debug [792d,6f48,0de1,0e00,45e1,4000]
System Diagnostic Reports
Safari_2012-06-07-185312_Whizzer.hang
Date/Time:       2012-06-07 18:53:01 +0100
OS Version:      10.6.8 (Build 10K549)
Architecture:    x86_64
Report Version: 7
Command:         Safari
Path:            /Applications/Safari.app/Contents/MacOS/Safari
Version:         5.1.7 (6534.57.2)
Build Version:   2
Project Name:    WebBrowser
Source Version: 75345702
Parent:          launchd [146]
PID:             471
Event:           hang
Duration:        5.76s (sampling started after 2 seconds)
Steps:           19 (100ms sampling interval)
Pageins:         15
Pageouts:        0
Process:         Safari [471]
Path:            /Applications/Safari.app/Contents/MacOS/Safari
UID:             502

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