The file is not readble - error message in Illustrator CS5

My wife worked on an Illustrator CS5 file for an upcoming after school program last night, then saved and closed.  This morning she tried to fine tune it before work and was presented with this message in a pop-up . . . The file is not readable . . . and in the meantime, not only is her heart is in her throat but her assistant principal jumping up and down as if it she had done something wrong.  Since we use the original Illustrator CS at work I offered to try and help but of course, cannot open CS5 files.  Anyway, I promised to research and try to find a solution and am posting here following submitting a bug report to Adobe about the issue.
Finally, is this rare or nearly unheard of?  I searched and found a similar thread back in May 2010 but sadly, didn't see a resolution.  On the other hand, I don't see these forums lit up with others suffering form this issue either and thus, presume this a weird one, or a one-off because everybody else isn't complaining.
Any help or advice would be gratefully received.

Happens occasionally, nothing special in CS5 to cause this. This document cover most of the things you can try:
http://kb2.adobe.com/cps/320/320318.html
And also renamke your file to xxx.pdf and try to open in Acrobat, then so a save as newfilename.pdf try to open in Illustrator.

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