The file may be read only

Every so often (approximately every one in three times I try to save), I get the message 'The file may be read only, or another user may have it open. Please save the document with a different name or in a different folder'. If I carry on working and then try to save it a few changes later, it sometimes successfully saves the file. Often it takes several attempts, but eventually it does save it. This happens with all my Illustrator files, they aren't read only and another user doesn't have them open. I'm using a trial version of CS5 and Windows 7 on a personal PC (I still have CS4 installed too - I don't know if it's something to do with this). Anyone have any idea what could be causing it?

It may be that you were using a font temporarily that was located in a directory that was read only or an image that was placed in the fie or another type of art placed in the files that may have the permissions restricted by accident. It could be that the scratch disk contains some sort of file that you are using and it has a restriction on the permissions as well.
Check to see if there is permissions problem on any of your directories or folders.
There may also be the possibility if you are e-mailling samples of the file that it is in use or at least your system and ai thinks so.
But it mostly sounds to me like the scratch disk needs to have the permissions corrected and that after a few attempts you end up clearing the cache so it is no longer using the scratch and then you are able to save it. Now I am not an engineer but this makes sense to me.
But it may simply be a problem with the settings folder and yiu can try this as well.
1. Quit Illustrator.
2. Rename the AIPrefs file (for example, to AIPrefs.old) in the Users/(user)/AppData/Roaming/Adobe/Adobe Illustrator CS5 Settings folder.
3. Start Illustrator. Illustrator creates a new preferences file.

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