The macbook will not start.

The macbook will not start. begins with "Deng", then the initial blank screen with flashing folder and question mark. Unfortunately, the DVD player is dead. I tried with a USB external drive and the installation disk but nothing happens (keys, C, D or N). I managed to get the mouse pointer on a blank screen by holding the alt key at startup.
My impression is that the disc is filled abnormally and can no longer boot. Probably jumped the permissions. I explain: the disk was almost full. Then my wife tried to connect to a site (German) images (art history) who was struggling to load the large amount of data downloaded. At that point the machine was stopped and forcibly turned off. From the day after is no longer divided.
I have no idea how to do it again and all attempts have failed. As a last test I can try with another mac connected and with the T key pressed (target). But I ask: can I connect with a USB-USB cable?

Thank's for answer.
The internal DVD player is broken. I have an external DVD drive (USB). I have the install DVD for the OS. But the evidence that I did not have success. What evidence do you recommend? May you confirm that the USB connection is useless? We need a firewire cable crossed?

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