The mouse can't select and operate any apps

Sometime the mouse will suddently freezes, can't select and operate any apps(include the dock). Although the mouse is moving, but I even can't operate force quit. Force quit can only be seleted though keyborad and I can only press power button restart to solve.
Here is my process:
Active Memory: 1.67 GB
Free Memory: 348.7 MB
Wired Memory: 903.1 MB
Used Memory: 3.66 GB
Inactive Memory: 1.10 GB
Total VM: 304.45 GB
Number of processes: 123
PID    Process Name              User       CPU      Real Mem        Virtual Mem
0      kernel_task               root       3.6      338.3 MB        5.47 GB
1      launchd                   root       0.0      3.1 MB          2.36 GB
11     UserEventAgent            root       0.0      4.2 MB          2.37 GB
12     kextd                     root       0.0      4.9 MB          2.35 GB
14     notifyd                   root       0.0      1.7 MB          2.36 GB
15     securityd                 root       0.0      8.9 MB          2.37 GB
16     diskarbitrationd          root       0.0      1.8 MB          2.35 GB
17     configd                   root       0.0      4.7 MB          2.35 GB
18     powerd                    root       0.0      2.1 MB          2.37 GB
19     syslogd                   root       0.0      1.3 MB          2.36 GB
20     cfprefsd                  root       0.0      1.7 MB          2.35 GB
21     distnoted                 root       0.0      2.2 MB          2.37 GB
22     opendirectoryd            root       0.0      19.6 MB         2.38 GB
25     warmd                     nobody     0.0      6.0 MB          2.35 GB
26     usbmuxd                   _usbmuxd   0.0      2.4 MB          2.36 GB
29     stackshot                 root       0.0      1.3 MB          2.35 GB
30     SleepServicesD            root       0.0      1.6 MB          2.35 GB
32     revisiond                 root       0.0      2.8 MB          2.37 GB
37     mds                       root       0.3      125.8 MB        2.83 GB
38     mDNSResponder             _mdnsrespo 0.0      6.3 MB          2.38 GB
41     loginwindow               2878451    0.0      27.2 MB         2.50 GB
43     KernelEventAgent          root       0.0      1.1 MB          2.35 GB
45     hidd                      root       2.7      3.0 MB          2.35 GB
46     fseventsd                 root       0.0      4.8 MB          2.38 GB
48     dynamic_pager             root       0.0      784 KB          2.32 GB
51     appleeventsd              _eppc      0.0      2.8 MB          2.37 GB
55     awacsd                    root       0.0      7.8 MB          2.37 GB
56     autofsd                   root       0.0      1.9 MB          2.35 GB
57     apsd                      root       0.0      8.4 MB          2.37 GB
58     karl                      root       0.0      4.5 MB          642.2 MB
60     com.avast.proxy           root       0.0      3.1 MB          2.35 GB
62     com.avast.fileshield      root       0.0      1.2 MB          2.35 GB
63     com.avast.MacAvast.MAD    root       0.0      3.4 MB          620.0 MB
68     coreservicesd             root       0.0      28.7 MB         2.39 GB
101    WindowServer              _windowser 7.3      89.7 MB         2.93 GB
102    CVMServer                 root       0.0      1.8 MB          2.38 GB
104    launchd                   _windowser 0.0      868 KB          2.36 GB
108    cfprefsd                  _windowser 0.0      1,004 KB        2.34 GB
117    ntpd                      root       0.0      1.3 MB          2.32 GB
118    cron                      root       0.0      832 KB          2.32 GB
119    SystemStarter             root       0.0      1.1 MB          2.35 GB
124    socketfilterfw            root       0.0      3.7 MB          2.37 GB
200    networkd                  _networkd 0.0      1.3 MB          2.35 GB
209    logind                    root       0.0      1.9 MB          2.35 GB
221    com.avast.MacAvast.MAD    root       0.2      92.2 MB         776.3 MB
234    launchd                   root       0.0      892 KB          2.36 GB
253    distnoted                 root       0.0      1.5 MB          2.37 GB
298    launchd                   _spotlight 0.0      888 KB          2.36 GB
301    distnoted                 _spotlight 0.0      1.5 MB          2.37 GB
302    cfprefsd                  _spotlight 0.0      1.1 MB          2.35 GB
303    launchd                   2878451    0.1      1.7 MB          2.36 GB
306    distnoted                 2878451    0.0      4.1 MB          2.37 GB
308    cfprefsd                  2878451    0.0      2.6 MB          2.35 GB
315    UserEventAgent            2878451    0.0      15.8 MB         2.39 GB
320    pboard                    2878451    0.0      948 KB          2.33 GB
322    Dock                      2878451    0.0      40.9 MB         2.48 GB
323    talagent                  2878451    0.0      7.9 MB          2.39 GB
324    SystemUIServer            2878451    0.0      29.1 MB         2.63 GB
325    Finder                    2878451    0.0      27.1 MB         2.48 GB
326    coreaudiod                _coreaudio 0.0      7.6 MB          2.38 GB
328    fontd                     2878451    0.0      6.8 MB          2.40 GB
331    Photo Stream              2878451    0.0      16.2 MB         2.40 GB
332    usernoted                 2878451    0.0      3.9 MB          2.37 GB
336    Notification Center       2878451    0.0      15.5 MB         2.42 GB
340    imagent                   2878451    0.0      6.1 MB          2.37 GB
341    helpd                     2878451    0.0      2.2 MB          2.37 GB
343    AppleIDAuthAgent          2878451    0.0      2.1 MB          2.35 GB
344    CalendarAgent             2878451    0.0      28.9 MB         2.39 GB
348    PenTabletDriver           2878451    0.0      10.9 MB         2.42 GB
349    KeyAccess                 2878451    0.0      5.0 MB          657.4 MB
352    com.avast.helper          2878451    0.0      10.6 MB         18.43 GB
358    accountsd                 2878451    0.0      5.4 MB          2.37 GB
360    iTunes Helper             2878451    0.0      3.9 MB          2.37 GB
361    xpcd                      2878451    0.0      6.7 MB          2.37 GB
362    filecoordinationd         root       0.0      2.7 MB          2.35 GB
364    NetworkBrowserAgent       2878451    0.0      9.0 MB          2.37 GB
374    GeekTool Helper           2878451    0.6      11.8 MB         2.43 GB
375    lsboxd                    2878451    0.0      2.2 MB          2.36 GB
379    SkyDrive                  2878451    0.4      26.7 MB         2.43 GB
380    kass                      root       0.0      4.0 MB          655.8 MB
382    imklaunchagent            2878451    0.0      4.2 MB          2.36 GB
383    tccd                      2878451    0.0      3.2 MB          2.37 GB
387    ConsumerTouchDriver       2878451    0.0      7.9 MB          2.39 GB
390    Dictation                 2878451    0.0      14.6 MB         2.40 GB
395    Speech Synthesis Server   2878451    0.1      24.7 MB         2.84 GB
396    TabletDriver              2878451    0.0      6.9 MB          2.41 GB
417    ScopedBookmarkAgent       2878451    0.0      3.0 MB          2.37 GB
418    Safari                    2878451    0.0      155.9 MB        3.98 GB
428    pbs                       2878451    0.0      7.1 MB          2.35 GB
429    launchd                   nobody     0.0      876 KB          2.36 GB
431    cfprefsd                  nobody     0.0      1.1 MB          2.35 GB
432    AppleSpell.service        2878451    0.0      7.5 MB          2.38 GB
448    Safari Web Content        2878451    10.5     589.6 MB        4.43 GB
460    com.apple.dock.extra      2878451    0.0      15.9 MB         2.40 GB
506    netbiosd                  _netbios   0.1      3.3 MB          2.36 GB
586    racoon                    root       0.0      2.2 MB          2.35 GB
2799   taskgated                 root       0.0      3.6 MB          2.37 GB
3413   cookied                   2878451    0.0      1.9 MB          2.35 GB
3428   Calendar                  2878451    0.0      40.9 MB         2.53 GB
4962   Microsoft PowerPoint      2878451    0.5      90.0 MB         980.8 MB
4967   syspolicyd                root       0.0      724 KB          2.35 GB
4981   Microsoft AU Daemon       2878451    0.0      2.6 MB          656.1 MB
7030   Dashboard                 2878451    0.0      109.6 MB        3.60 GB
8637   diskimages-helper         root       0.0      14.4 MB         2.37 GB
8643   hdiejectd                 root       0.0      1.8 MB          2.35 GB
10608 Trackpad Handwriting      2878451    0.0      51.0 MB         815.9 MB
11517 com.apple.iCloudHelper    2878451    0.0      6.0 MB          2.37 GB
11528 Flash Player (Safari Inte 2878451    1.0      111.6 MB        3.71 GB
11646 mdwrite                   2878451    0.0      3.4 MB          2.37 GB
11647 ubd                       2878451    0.0      12.8 MB         2.38 GB
11653 smcFanControl             2878451    0.4      11.2 MB         2.41 GB
11951 eapolclient               2878451    0.0      4.0 MB          2.37 GB
11952 ocspd                     root       0.0      14.8 MB         2.38 GB
11971 AirPort Base Station Agen 2878451    0.0      2.0 MB          2.35 GB
12183 com.apple.speech.synthesi root       0.0      4.3 MB          2.35 GB
12184 xpcd                      root       0.0      4.5 MB          2.35 GB
12530 mdworker                  2878451    0.1      15.8 MB         2.36 GB
13369 Quick Look Helper         2878451    0.0      7.1 MB          2.87 GB
13372 Activity Monitor          2878451    7.5      25.6 MB         2.46 GB
13376 activitymonitord          root       1.5      1.6 MB          2.33 GB
13377 Time Out Free             2878451    0.0      9.3 MB          726.5 MB
13393 mdworker                  _spotlight 0.0      5.0 MB          2.36 GB
13396 automountd                root       0.0      1.6 MB          2.34 GB

Back up all data, then uninstall "Avast" according to the developer's instructions. Reboot and test. Even if there's no improvement, I recommend that you never reinstall Avast.

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