The mouse locks up when PC left alone for over an hour. Help!

We got a HP505B Microtower PC /Windows 7, Every time we try to login to PC and it's been about an hour since PC was unused  the mouse is locked up, it wont respond.  We've swapped the mouse, plugged on a different USB ports and the same thing happens.  Rebooting the PC works, but its a pain to do it more than once a day.  Is this happening to anyone else?  Can anyone offer some advice?  Much appreciated.

Hi,
A number of issues you could cause your problem.
1. Excessive heat
2. Bios bug
3. Video driver bug
4. Power options set incorrectly
5. Memory errors
6. Power supply issue
7. Freaky software issue
Boot up your PC into safe mode (F8) and let it sit for an hour and see if the issue occurs.
HP DV9700, t9300, Nvidia 8600, 4GB, Crucial C300 128GB SSD
HP Photosmart Premium C309G, HP Photosmart 6520
HP Touchpad, HP Chromebook 11
Custom i7-4770k,Z-87, 8GB, Vertex 3 SSD, Samsung EVO SSD, Corsair HX650,GTX 760
Custom i7-4790k,Z-97, 16GB, Vertex 3 SSD, Plextor M.2 SSD, Samsung EVO SSD, Corsair HX650, GTX 660TI
Windows 7/8 UEFI/Legacy mode, MBR/GPT

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