The program did not start on the remote computer. For assistance, contact your system administrator RDS 2012

The issue is when a USER tries to open a program, and it's mapped to a network drive T:\fixedast\app.exe they get the tittle error message. If i log in as admin, it opens up just fine. Ideas? The user can remote desktop to the RDS server and open the application
correctly. I'm a bit lost. Ideas?

Hi Fred,
Thank you for posting in Windows Server Forum.
Have you created any batch file for user to run the program?
Based on my research, the problem which you are facing is caused because the program is hosted on or depends on a network mapped drive. When starting a RemoteApp the program doesn’t wait till the logon script is finished but just start the program directly
and cannot find the right drive or program. To work around this issue you can create a batch file as RemoteApp so you can first map the network drive and then start the program. 
Apart you can check whether user has rights for mapped drive or they are not missing the mapped drive. Refer below article for more information.
How to restrict users from accessing local drives of an RD Session
Host server while using RemoteApp programs
Hope it helps!
Regards.

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