There is a problem with your mailboxes. Try clicking Quit-

"There is a problem with your mailboxes." "Try clicking Quit and then opening Mail again. If this message reappears, click Quit and Rebuild index. The next time you open Mail, it will import your messages."
This error has become more frequent every day as I use Mail. Luckily, I found through another thread in this Help Discussion Forum that the Avast Security App for Mac has a hard time with large mailboxes in the Mail.app:
http://discussions.apple.com/thread.jspa?messageID=9477497&#9477497
The solution appears to be as simple as un-checking "Mail Support" in the Avast "Preferences…" and the issue will be resolved.

Answered!

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