Thunderbird keeps showing 'Not Responding' on all my computers.

Trying to access TB on my laptop last night all I got was 'Not Responding' which effectively locked me out of my email. Today in the office I find my other two computers are the same. TB seems to be reloading the same email time after time, presently I have about 4 versions of each email on the screen but every time I try and access them I get the same 'Not Responding' message followed by screen whiteout.
My business depends on my email account I am desperate.

First off the screen went really weird with everything three times the normal size. I managed to start windows in safe and then started TB. However since I wasn’t connected to the internet and the computer would not connect I don’t know how much use that was.
I started TB in safe and although it loaded I could do nothing with it as the mouse had no function, I couldn’t click on anything, move anything or close anything down.
I appreciate your help this is getting very serious for me now.

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* https://wiki.mozilla.org/Thunderbird:Testing:Antivirus_Related_Performance_Issues#McAfee
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== URL of affected sites ==
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Thunderbird keeps showing 'Not Responding' on all my computers.

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