Thunderbird not reponding; can't open,deleat, mail etc.

I cannot open mail on thunderbird, I click to open an email and nothing happens, I try again and the entire screen becomes shaded in a light gray and the circle symbol appears. I have archived all emails from 2012 and before. Plenty of space. Rebooted several times and still cannot open mail.
It had been working just fine.
Thanks

re: ''entire screen becomes shaded in a light gray and the circle symbol appears. ''
Thundrebird is probably not responding because it is still processing emails or there is a background process.
''re:I have archived all emails from 2012 and before.''
Have you also done the same with the Sent folder?
Do you use IMAP or Pop mail accounts?
Make sure have a backup.
compact all folders.
File > compact folders.
Do you use an anti-virus software?
If yes, what do you use?
Suggest you stop scanning emails.

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