Tricky - PDF file not Opening from Web Browser based application

Hi Guys,
Just a brief history about the issue:
At my client site everything was fine when IE7 was there and everybody were able to open PDF files from web applications in browsers. But after a IE8 upgrade, things changed and customers are facing problems. All are Windows XP SP3 machines
Issue: If they try to open a pdf file from the browser it just stucks at 0% and hangs with "Cancel" button. Even if they try to save that file it tell downloading and hangs again in the screen without downloading the file.
Initial fix:
Open Adobe Reader
-> select the menu "Edit"
-> select "Preferences"
-> select the Category "Internet"
-> set the indicator "Display PDF in browser"
-> Reboot the machine
This fix worrked for some people but many user are still experiencing the same thing even after changing the setting many times.
Friends, Is there anything else might be creating the trouble here. Please let me know, and why it is that for some systems it is working and for it is not ?
Thanks,

There was a browser bug with IE in the past that seemed to span several browser versions.  It had to do with the interaction of the browser and the webserver.  The short version is that I had to toggle the caching option on the folder.
Here's what I ended up doing for my client:
Move their PDF documents into a subfolder called forms and all Flash animations into a subfolder called flash
Marked all folders in the site to "Expire Immediately" (IIS -> highlight root folder -> Properties)
Individually marked the "/forms" and "/flash" folders to toggle this caching option
In this way, it allowed dynamic pages to deliver non-cached content (from the server's perspective) and it allowed binary downloads like Flash animations and PDF files to work as expected without errors.  The bug has to do with the cache-negotiation handshaking that goes on between the browser and server.
This may not be what you're seeing but it's good to remember because I've seen it often:  the settings that you'd use to optimize a web applications don't seem to work for binary downloads like a PDF document.

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