Trying to install itunes on windows vista and get the following error message:

Trying to install itunes on windows vista and get the following error message: An error occurred during the installation of assembly "Microsoft.VC80.CRT,version="8.0.50727.4053",type="win32",publicKey Token="1fc8b3b9a1e3b",process orArchitecture="x86"". Please refer to Help and Support for more information. HRESULT: 0x80070424.

A broken Windows Modules Installer then. It's a bit of an involved fix getting past it, but we've had success here with it in the past.
First, I'd strongly suggest setting up a system restore point.
Now try the Scenario III treatment from the following document:
Windows Update Error 80070424 in Vista
Head back into Windows Update and attempt to get updates again. If they still fail, this time with an 8000FFFF error code, try the following Microsoft document:
Windows Update error 8000FFFF
If you get Windows Updates flowing again, stock up on any you're behind on (restarting the PC when requested to do so). This may take some time and may have to be done in several batches, depending on how far you've fallen behind. Basically, keep going back to Windows Update until it stops offering you new updates.
After the updates have been installed, restart the PC one more time (in order to ensure that any pending installs requiring a restart have been resolved).
Now try another iTunes install. Does it go through without the 0x80070424 this time?

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