Twain not working since update to os x 10.8.3?

Hi All.
Another query for you.
I've recently updated one of my 2 iMacs form 10.8.3 to 10.8.4.
Previously I'd been using Photoshop CS3 for my scanning (Photoshop CC is a bit heavy for my mid-2007 iMac and 'Import Images from Device' is a bit unpredictable).
Twain plug-in worked fine with my Epson Perfection 4490 Photo scanner.
It still works fine on the iMac running 10.8.3 - but I can't get it working on the iMac running 10.8.4?
Can this be right? Is this (minor?) upgade affecting my Twain plug-in in some way? Or am I just missing some detail when I re-installed Photoshop CS3 + Twain plug-in?
All thoughts / advice gratefully received,
thanks,
P

What's currently installed on her mode? Which exact model does she have? What is the hardware configuration? Does it meet the minimum requirements:
Upgrading to Mountain Lion
To upgrade to Mountain Lion you must have Snow Leopard 10.6.8 or Lion installed. Purchase and download Mountain Lion from the App Store. Sign in using your Apple ID. Mountain Lion is $19.99 plus tax. The file is quite large, over 4 GBs, so allow some time to download. It would be preferable to use Ethernet because it is nearly four times faster than wireless.
     OS X Mountain Lion - System Requirements
       Macs that can be upgraded to OS X Mountain Lion
         1. iMac (Mid 2007 or newer) - Model Identifier 7,1 or later
         2. MacBook (Late 2008 Aluminum, or Early 2009 or newer) - Model Identifier 5,1 or later
         3. MacBook Pro (Mid/Late 2007 or newer) - Model Identifier 3,1 or later
         4. MacBook Air (Late 2008 or newer) - Model Identifier 2,1 or later
         5. Mac mini (Early 2009 or newer) - Model Identifier 3,1 or later
         6. Mac Pro (Early 2008 or newer) - Model Identifier 3,1 or later
         7. Xserve (Early 2009) - Model Identifier 3,1 or later
To find the model identifier open System Profiler in the Utilities folder. It's displayed in the panel on the right.
     Are my applications compatible?
         See App Compatibility Table - RoaringApps.

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