Unable to edit files in Sharepoint

Hi,
When I try to edit a file, I get a pop up asking me to open the file, which I accept, then Excel, or Word, asks for my login. Then I get "Sorry we couldn't open XXXXXXXXXXXXXXXXXXXXX.XXX"
Clicking OK presents:
"Microsoft Excel cannot access the file 'XXXXXXXXXXXXXX.XXX'. There are several possible reasons:
* File name or path does not exist
* The file is being used by another program
* The workbook you are trying to save has the same name as a currently open workbook"
This used to work fine, but upon returning from the Christmas break, this is the error.
Ticking the file in sharepoint, then clicking files and download copy works and is prompted for a file download to start.
Similarly if I go to Open in Explorer under Library, it opens an explorer window with the files. Double clicking them yields the same error as above.
If I go to Excel, Open, Other Web Locations, then I have recent folders showing my sharepoint details, clicking into this shows the files and allows me to edit, save etc.
Does anyone have any idea what's wrong?
Many thanks :)
Jon

I agree with Andrew. You may also want to add the Checked Out too Column to your views.
Please also be aware that if the file has been opened bt someone that's then wondered off for Christmas and left it open, there may also be a lock on a network level applied to the file, rather than this being applied on a SharePoint web app level.
Steven Andrews
SharePoint Business Analyst: LiveNation Entertainment
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