Unable to edit SharePoint document in desktop applications

A number of our users are reporting issues when trying to edit Excel or Word documents that are stored on SharePoint via their Desktop applications. The error is as follows 
Error 1: "Sorry, we couldn't open [file location here]"
Followed by:
Error 2: "Microsoft Excel cannot access the file [file location here] There are seveal possible reasons:"
We are running Windows 8 and I have tried resetting IE settings back to default and removing all Windows Credentials (well, only those relevant to Office). If I remove the credentials I get asked to sign back in, which I do. 
Any ideas what else we can try?

PLease try with office 32 bit version. 64bit sometime create issue.
Regards Sudip Misra [email protected] +1-412-237-5435 Pittsburgh, PA

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