Unable to initialize Photoshop because the preferences file has been removed

Hello
After a week without using photoshop, I can no longer open it. As soon as I try this message appears: "Unable to initialize Photoshop because the preferences file has been removed."
So, I went to look for this preferences file that I've never deleted and I can't find it.
I tried to reset photoshop with keyboard shortcuts preferences,  it does not work. I also uninstalled and reinstalled the software, it does not work either.
What else could I do ...?
Thank you for your help.

lola.marceau wrote:
I tried to reset photoshop with keyboard shortcuts preferences,
Seems odd that such a problem would crop up on its own.  That kind of sounds like a registry or permissions problem.  What other things did you do with the computer between the time it worked and it didn't?
And if you're willing to uninstall / reinstall to try to recover operation, it might be prudent to try the Adobe cleaner tool to really be sure you've uninstalled everything...
http://helpx.adobe.com/creative-suite/kb/cs5-cleaner-tool-installation-problems.html
-Noel

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