Unable to open any kind of file once I have downloaded it using Firefox 4

I have noticed that, since switching to Firefox 4, I am having trouble opening files (ANY kind of file) either straight from the link or after downloading and saving them to my hard drive while using firefox (for instance, Word, Powerpoint, or Adobe documents from my school's curriculum page) . I get an error message when I open them, with the intended application usually telling me that the "file cannot be opened." When I try to download the same files using Safari, they download and open just fine. What's really weird is that I don't have this problem all the time. Sometimes I will try to download a file and I will get an error message, and then 30 minutes later after making NO changes, it will download and open just fine. I have the problem more often then not, though. I have noticed this happen on several different wireless networks.
Thoughts? Thanks in advance.

To get any plugins out of the troubleshooting equation, hold down the Shift key and start Photoshop. If Photoshop functions normally, you'll want to look at those.
There is the keyboard method of resetting Preferences and there is moving or deleting the actual preferences folder as described here:
FAQ: How do I reset my preferences?
For some that solves the problem where the keyboard reset did not.
In any case, being forum volunteers, we would not be able to access your computer the way Adobe Support can. We do well for many problems, and that saves time for a great many, but there are cases where the problem might some place unfamiliar to a lot of us.
If nothing can get done here, I hope Chat can do better.

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