Unable to open applications: error code -10810

For some reason I have started to have problems opening up applications after my computer has been on for around 10 minutes. I am able to open up apps at startup, but after they've been running for a while, if I try to open additional apps (from either the doc or the apps folder) I get a pop-up error window with the code "-10810". This number shows up in all the error windows.
I've tried to do some research on this and found a couple of articles saying to delete the following:
/Library/Caches/com.apple.LaunchServices.6B.csstore
~/Library/Preferences/com.apple.LaunchServices.plist
(where '~' means your Home directory, i.e. '/Users/yourname')
but I don't have this particular file.
Can anyone help me? This problem just started today, but I've been running Leopard for about a month now.

Was able to startup TM again my pressing the Control key while clicking the TM app icon. A pop-up menu appeared from which TM Preferences was selected. It appears that error code -43 is akin to a external HD that is not mounted. All is well again

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