Unable to open iSync: "Not supported on this platform"

Maybe it was the 10.5.5 upgrade, maybe not. Right now, when I click on iSync, I get an immediate popup saying "You can't open the application 'iSync' because it is not supported on this architecture. Well, it was a month ago. I use iSync to set the threshold of changes on my calendar that result in a confirmation notification. When I sync my iphone, I want to know if the sync process is changing more than 2 calendar events.
Can anyone help me out?

Thanks for taking the time to reply
This is an Intel MacMini
iSync was located in the Applications folder and has lived there all its life. I tried moving it to the desktop and then back to the Applications folder, like you suggested. I still get the "Not supported on this platform ..." message. I'll re-apply the 10.5.5 update in the morning.
I agree that some apps hate to be removed from the Applications folder. I have tried to move some Apps to the Utilities folder unsuccessfully before.

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