Unable to open PDF in Adobe XI

I am unable to open certain PDF files in Adobe XI.  We're using Windows 8.1.  Any ideas?

Do you get these "certain" pdf's from the same place or is there anything else they may have in common?
Are they on your computer or are you trying to open them from a browser? If a browser, which one? What exactly happens when you try and open them?
And since it's Windows 8 I have to ask whether you are sure that Reader is attempting to open these pdf files and not the built in default windows Reader app?

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