Unable to send mail to outside domain users

Hey Folks,
Does anyone has a clue why OCS won't relay email message outside the domain?
I successfully completed a single box OCS R2 install on Redhat AS 2.1 kernel 2.4.9-e5. Everything works fine except sending email outside of the domain.
Thanks in advance for the help.
Rene

I'm getting the following message once I click on "SEND" to e-mail to an existing yahoo e-mail.
Error : Your message has not been sent because of unknown recipient(s). Please correct the email addresses of your recipient(s) and re-send.
<username>@yahoo.com
I increased the trace level on the SMTP_OUT to 30 but still not getting explicit info on that behavior, except some Trace 21 and 22 with no clear meaning.
Thanks,
Rene

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