Underestimating disk space when installing applications

Dear all,
I am attempting to intall a windows-native application upon the bootcamp partition of my hard drive, which was allocated 20GB. I have 12GB of free space remaining, as reported when I click "properties" on my C: drive. The installation wizard for this program informs mee that I do not have enough hard disk space to install the program, which requires 200MB, and I cannot complete the installation without convincing this wizard that there is, in fact, sufficient disk space. Any insight into why the wizard might underestimate the space available? Thanks in advance.
-Ben

Not a very common one... a biotechnology application called Primer Express. The manufacturers of this program have not been very helpful.
-Ben

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