Unknown Error 13010 prevents me from opening itunes.

I was using itunes, then closed the application. Then I was typing a message in msn messenger, and the window saying that itunes was saving the library popped up while I was typing and it's like typing while that popped up did something to it, but that saving window has no buttons to push. Then windows tell me (in a window on the bottom right side of the screen) telling me the data could not be saved and was lost (external drive where the library and everything is located) mentioning the file and to try and save it elseqhere E:\$Mft but how can I do this when I don't know what the f this file is and how to access it or do anything with it? If I click on the message, it disappears, and if I try to open itunes, I get the error message 13010, to which I can only say OK, and after that, I get the Windows warning that the data could not be saved and the Mft thing again. Vicious circle.
What the **** happened?
After a while I notice that, kinda like windows said in the window, the connection to the drive was lost (but HOW???), because I can't access anything in the external drive. So I unplugged it and plugged it back and now it works.
But what happened?
(I've got itunes 9)

Joe ~
"It turns out I was working with a corrupt ePub file. I was able to install a different German edition on my iPad with no problem. I'm not sure if the "-23" refers to a bad ePub file but if you see this during a synchronization you should also see another message referring to the file that caused the error. Check the source of that file to make sure it's legit. If possible, download a new version and see if the problem goes away. That's what worked for me."
...Found by doing THIS.

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