Update *always* fails. Deleting files, run as admin don't work

I can *never* get the update to work. I always get the message: "The update could not be installed. Please make sure there are no other copies of Firefox running on your computer, and then restart Firefox to try again." I have the same issue with Thunderbird. I'm running on Win 7 64 bit. My normal login account has admin privileges.
I have tried all the work arounds listed (eg deleting update folder, etc). Nothing works and I always have to download and do a full install.
It's very, very frustrating.

It is a problem with the Firefox program folder (C:\Program Files\Mozilla Firefox\), so no need to check the profile folder.
If there are problems with updating then best is to download the full version and uninstall the currently installed version and delete the Firefox program folder to remove any leftover files.
Download a fresh Firefox copy and save the file to the desktop.
*Firefox 10.0.x: http://www.mozilla.org/en-US/firefox/all.html
Uninstall your current Firefox version, if possible.
*Do NOT remove personal data when you uninstall the current version or you lose your bookmarks and other data because all profile folders will be removed.
Remove the Firefox program folder before installing that newly downloaded copy of the Firefox installer.
*It is important to delete the Firefox program folder to remove all the files and make sure that there are no problems with files that were leftover after uninstalling.
*http://kb.mozillazine.org/Uninstalling_Firefox
Your bookmarks and other profile data are stored elsewhere in the Firefox Profile Folder and won't be affected by a reinstall, but make sure that you do not select to remove personal data if you uninstall Firefox.
*http://kb.mozillazine.org/Profile_folder_-_Firefox
*http://kb.mozillazine.org/Profile_backup
*http://kb.mozillazine.org/Standard_diagnostic_-_Firefox#Clean_reinstall

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