Updated iTunes, computer restarted but now wont boot up.

Today the kids updated iTune on their mac, the computer restarted now its been stuck on the gray screen with the loading circle and apple symbol, when I tried to do a safe boot it went to the file with a ? on it.
I've tried most things that apple recommends doing, we updated recently to the newest OS but we have no install disks.
Apart from dragging a 24" into the city to get fixed, are there any other options?
Thanks.

I've left it on for awhile now, the spinning globe (loading circle thing) has disapeared, the apple logo is still there, but does nothing else.

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