Updated Safari, now most apps are crashing at start-up

So I updated Safari on Friday, and I was unable to get it to run. It would always crash on start up, Since then I have 1 by 1 losing my other Apps. iWeb,Software Update, both crash on start-up, and in my System Prefernces my .mac and Network prefernces crash as well.
I have never been able to repair permissions since I upgraded to Leopard. I have however repaired permissions while booting up on a connecting firewire drive with 10.3, but it did not help. I have chucked all my preferences for the offending apps as well....what is next?
Cheers
-Allan

It sounds as if there are some repairs needed. If the Repair Permissions function has never worked, then something is awry and needs repair. When you install other applications on top, you could be adding to the instability and it sounds as if Safari has tipped the balance: now they are all going haywire.
I would consider first running the Repair Disk utility from the grey install disk; secondly applying (or even reapplying) the OS X 10.5.2 Combo update -- a heavy download I know, but it may be worthwhile; and running a stronger utility, like Disk Warrior (always a good standby).

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