Urgent Help Needed - Frozen disk drive & mouse

This is quite a complicated situation, but i will put it simply:
I woke my mac from its sleep, and went to connect to the internet(wanadoo broadband. It wouldnt do it and went from saying 'connecting....connecting...'on the finder bar in the right hand corner(next to where the time is)and said 'disconnecting...' over and over. This usually last a few seconds but 5 minutes later it was still doing it, so i went to restart the mac.
When it was restarting, it went to the login page, and it never does this, so i went to use the mouse to click on it, but it wouldnt move from the top left corner of the screen. So, i used the keyboard to select it and logged in. Once it had got into the finder the mouse still wouldnt move. The time kept coming on and then disappearing again over and over.
I have tried opening Norton Disk doctor but i can select any options because the mouse wont work and a live update comes up before it opens and i cant select the option of not to use it. I have tried several things, i restarted using the on/of button and no change, i have unplugged all the usb devices but nothing has changed.The disk drive wont open either when i click on the eject key. So i cant reboot from a disc because
1)disk drive wont open
2)I cant click on the apple in the top left corner to go to the restart option and then hold down any keys.
The only reason i am on the net is cos i have used my flat mates pc to hook up on the net so i can get some advice, the apple helpline wont help me as i no longer have apple care plan, and i dont want to go out and travel to a different city to get hold of a new mouse, if it isnt the initial problem.
I really need help because i have work to do and deadlines to meet and even though i have the work backed up on an external hardrive, i cant access it because what i am using is a pc and my work is formatted for a mac. I also didnt get round to backing up all my music from itunes, so i really hope it doesnt come to formatting my hardrive because i dont want to lose all my files.
Can anyone help me please? Im desperate

StreeX,
If you have time, search the Discussions for "Disk Doctor Kervorkian". Symantec Systemworks / Norton Disk Doctor is widely and consistintly blamed for making things worse, sometimes irrepairablly so. (So be grateful you couldn't select it.)
You wisely unplugged other USB peripherals, but did you try unplugging and re-pluging the keyboard and mouse? Also try disconnecting your Ethernet (and phone line if any). The only peripherals should be the keyboard and mouse.
Does the mouse's red LED light up when the computer is on? Try both with the mouse plugged into the keyboard and with the mouse plugged directly into the Mac.
You can force the optical tray to open by holding down the mouse button while starting up. It's also possible to carefully (and gently!) pry the drawer and then the tray open with a fingernail of X-acto type knife blade.
You can force the Mac to restart unconditionally holding down command-control-eject (see Magical Macintosh Key Sequences)
Can you get the Mac to start up in Safe Mode?
With the optical tray open you can try booting from youe OS X Install disc to run Repair Disk to check for errors. An alternative is to boot to single-user mode and run the file system check utility. Refer to Using Disk Utility and fsck.

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1. Since I reset the CMOS and now the system is starting fine on my last OC settings, is it safe to assume the sytem is stable for now?
2. I never made any power changes or BIOS changes after I installed the new cooler. Should I have?
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