Usb audio drop-out and problems on 2010 Mac Mini

Hello!  I recently purchased an Apogee Symphony USB audio interface for my Mac mini.  I have been trying for over a month to get it fully functional without having any dropouts.  The interface runs fine for about 15-20 minutes before I hear static (using my DAW, using iTunes, streaming movies on Netflix, etc).  Sometimes the DAW (reaper to be specific) can't play back because the computer lost the connection to the USB Audio interface.  I know this because I launch Audio Midi setup and it does not recognize the Apogee Symphony interface.  I restart the interface and it works fine.  There is intermittent loss at times, inconsistent latency, etc.  I have worked with Apogee support and we've tried everything - newest drivers, firmware update, etc.  I used to run Snow Leopard 10.6.8 and had the same issues; I upgraded to 10.7.5 but had major kernel panics due to the display (or something, couldn't quite figure it out) but I reverted to 10.7.4 and everything runs smoothly... except the audio interface.
This led me to doing some research online and I think the problem is with USB audio dropouts.  I've tried disabling Bluetooth, Airport, not putting my HD to sleep, etc and still has the same issues.  I've tried two different USB ports:  the one closest to the display and the the one next-to-last. 
My question is:  what causes the USB audio dropouts and is there a fix for it??

This happened a bunch of times; I only copied the main gist of the error message:
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: kIOReturnNotResponding
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: System          : 0x38
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: Sub          : 0x0
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: Code          : 0x2ed
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: sys_iokit error
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: sub_iokit_common
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: kIOReturnNotResponding
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: System          : 0x38
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: Sub          : 0x0
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: Code          : 0x2ed
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: sys_iokit error
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: sub_iokit_common
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: kIOReturnNotResponding
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: System          : 0x38
Jun  1 19:01:31 Franks-Mac-mini com.SymphonyIOUSBDaemon.plist[63]: *** process 63 exceeded 500 log message per second limit  -  remaining messages this second discarded ***

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