USB devices no longer connected

Since installing Snow Leopard I have had problems with my Epson R2880 printer. I downloaded a later driver and this worked for a few days but now it will no longer print from any application. My TomTom has also stopped working on USB.
The USB ports seem to be faulty, although the keyboard and mouse are OK, everything else fails to connect via USB. They all show up in System Profiler with correct devices attached but are not seen by the OS any more.
I have tried a reset of the PRAM and also disconnected everything and powered off for at least 2 hours.
Anyone familiar with this problem or have a fix?

I do have a powered USB hub but even direct connects stopped working. I have fixed the printer problem now after a number of attempts. I installed the new 10.6.1 patch for SL but this made no difference. I have now re-installed both Rosetta and the Printer Support from the install CD, both of these are optional but clearly very important.
Finally I downloaded again the latest Epson print driver and my printer is now responding. Unfortunately the TomTom still will not connect so I may try reloading that software too.

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