USB mouse button doesn't work on MacBook Unibody

Since the trackpad was not working, we have to use a USB mouse to navigate. After a few minutes, the mouse left and right button doesn't work. I can move the pointer around the screen and use the keyboard.
Thoughts

The same problem happens with a Bluetooth apple mouse. You can scroll up, down and use the secondary (the right click) The problem normally developes after the MacBook has been running for a while and gets hot underneath.

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