Vanishing sent messages in Apple Mail 4.3

I'm using Mac OS 10.6.4 with Apple Mail 4.3 and I've experienced a bug recently. I noticed that some of my messages, either new ones from scratch or replies to received messages, simply vanished.
If the message was a reply, I can't find it back by clicking on the curly arrow next to the name of the original message. A friend also experienced the same problems and we unfortunately can't replicate or find a logic to this bug. Searching doesn't do the trick, I'm using IMAP and it's also gone on the server but people receive these messages apparently.
Technote: MailTags and Mail Act-On are installed.
Has anyone experience the same problem and manage to isolate the cause of it? Thanks in advance for your help.

I lost everything - inbox, sent, junk, trash - everything. And, one email newsletter I subscribe to sent an email (which eventually vanished) informing me that my subscription to the newsletter had been cancelled - but I didn't cancel it. I suspect that incoming emails, including the newsletter, were returned (or bounced) resulting in the cancellation.
This is a very serious issue Apple needs to address immediately. Mail 4.4 and MobileMe mail are affected, or infected, so now I've set all incoming emails to also be forwarded to a horrible Hotmail account I've had for years. That's the only way I get them.

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    Frank Lowney  
    To: Frank Lowney
    X-Ms-Exchange-Organization-Network-Message-Id: b1df37ac-a511-45ef-a6b9-08d1e12fdda0
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