Virtualbox on Mountain Lion with Mac os x server

Hi,
Got a problem since migrated to Mac OS X Mountain Lion with in addition OS X Server application installed to replace Mac OS X Lion server on a Mac Mini.
All was working fine until the day after the installation I got the following message when I start VirtualBox:
Failed to initialize COM or to find the VirtualBox COM server. Most likely, the VirtualBox server is not running or failed to start.
The application will now terminate.
Callee RC:
NS_ERROR_FAILURE (0x80004005)
On my MacBook Pro I did the upgrade to ML too, but without the upgrade of the Lion Server to OS X Server.
SInce a number of things have fundamentally changed (X11 removed) I wonder what I need to do to get my Virtualbox working again and what is the **** difference that the installation of the server component causes.
There have been issues with the support of Virtualbox but the testlevel was set to 4.1.15 ... so the version I'm using 4.1.18 should work ... but I don't see any kind of verification against OS X Server.
Been looking for a day now and haven't got a clue anymore where to look.
Are there people out there having the same kind of problems?
Thanks in advance,
Jan

I am having a similar "Failed to initialize COM" problem on Mac OS X 10.7.5, VirtualBox 4.2.2. I have wasted over six hours alone trying to address the issue, and it's still unresolved. My message:
Failed to initialize COM because the VirtualBox global configuration directory /Users/username/Library/VirtualBox is not accessible. Please check the permissions of this directory and of its parent directory.
The application will now terminate.
There is no such VirtualBox folder in my user Library folder. It is trying to locate a non-existent directory.
The closest workaround I could find that enabled VirtualBox to open was to create a brand new admin level user, log in to that user account, then install VirtualBox and run under that account. Works great, until I log out and try to run VirtualBox on my primary admin account, which results in the same "failed to initialize COM" error.
I have found no helpful advice geared towards Mac OS X users to troubleshoot or resolve this issue. You can try posting on Oracle's VirtualBox forum. Good luck.

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