Weird: changing file or link associated defaults then changes ALL defaults to the same program

Y'know... I thought I'd possibly 'seen it all' but today someone brought me a laptop with something I don't believe I've ever seen...
every link and file association is defaulted to the wrong program, and it is not possible to restore the association to the proper program for the respective file types.  And changing one
association changes ALL other associations for every other link to a file or shortcut.
For instance: 'right-clicking' on what I KNOW to be an Adobe Acrobat file and selecting 'open with...' from the context menu, Adobe Acrobat is not shown (even after un-installing and re-installing Acrobat).  So I 'browse' to the Program files (x86)
folder and select Adobe Acrobat (AcroRd32.exe) from within the Adobe Acrobat program folder to 're-associate' .pdf files with Acrobat..  BUT - this then changes ALL associations for everything  (including shortcuts on the desktop) to Adobe Acrobat.
  And the same can be said if I attempt to change the file association for a "docx" file extension (MS Word document).  Change the 'association' for one single 'docx' file and this results in ALL files or shortcuts on the desktop to also
change to MS Word.
So - what the ...?  Anyone have a clue as to what he's done on this "brand new" installation of Windows Home Premium (64-bit)?  I only just (this past week) talked him into 'abandoning' XP in favor of a license of Windows 7 Home Premium,
and afterwards everything was 100% and fully operational - but now one week later and he's done this...
So...  A registry issue..? Something to do with 'file association' defaults? (and my suspicion is some sort of 'dll' problem with this performance and the issue of not being able to configure 'program defaults' for any given file type without also affecting
all other associations...).
So,short of backing up all his data (out of precaution) and trying to do a 're-installation' of Windows, my most immediate response with this would be to just 'blow it away' and re-install Windows again ... and then copy all of his data back to the corresponding
locations.  But I would like to know what he's possibly done (for future reference) and maybe learn of some possibility that this can be 'fixed' and the correct 'associations' re-established without having to re-install Windows one more time...
GAA! THIS is why I shave my head...

Hi,
According to the description, it seems that the issue is caused by some corrupted registry entry\keys, a corrupted registry key can be caused by an malware\virus, or an bad-coded program or just some incorrect operation by the user. it's hard to determin
which is the culprit, but we can try to repair it as we could.
Please refer to the following link and see if it helps, (backup your registry first before editing the registry)
http://support.microsoft.com/kb/950505
we can also create a new user profile instead and copy files and setting from the old profile
http://windows.microsoft.com/en-in/windows/fix-corrupted-user-profile#1TC=windows-7
Yolanda Zhu
TechNet Community Support

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