What are the penaltys to operating lion from a remote drive?

My Macbook pro with Lion installed  is runing slower and slower and I have tried all of the fixes that I can find on the internet including, clearing the SMC, resetting the PRAM, defraging my 1 TB internal disk, run Kaspersky, run Mackeeper, fixing permissions. I have done all of these multiple times without much improvement if any. There are times when I can type a sentence into mail and watch as the program runs one or two words behind my typing. I have 8 Gig of memory, 2.66 intel dual core. The rotating spere is my worse enemy and I am sick of it.
I need to run Windows 7 in a paralles VM much of my work time. I use the computer for architectural work and I run an Autocad Program called Revit in the VM. Other times, I need to use Photoshop CS5 and Lightroom in the Lion enviroment. I never try any more to have the VM running and photoshop at the same time - I could go on vacation and back before I get the machine to respond in that circumstance. I have tweated the amouts of memory allowed to both without seeing any real change. I suspect at times video card problems but have turned off acceleration in the Autocad enviroment to get around it.
The one thing that I haven't done and don't want to do is a clean install of Lion. This problem has been progressive and I doubt if the problem orginates with Lion but who knows? So I got this idea, I could install Lion on a cleaned 500 GB remote drive and then install Paralles and Windows 7 in that version of Lion. Then I could boot from the remote drive where there is nothing else installed and Paralles/Autocad/Lion would have total free access to all of the resources of the computer by itself. Do you think this will work? I realize that it would have no effect on the programs installed and their slow response time for the internal drive but I could almost live with that.
If this improves proformance for Autocad on the remote drive, does that imply that a clean install of Lion on my internal drive would fix the current problems? I do not want to go to a windows POS to solve this problem with all of its inablity to start up and shut down and blue screens - been there, done that. But frankly, I'm not that far away from the same kind of time wasting computer issues with my Macbook.
Any help will be appreciated and I am willing to try almost anything.
steve
If you note a tone of disperation in my comments - you got it right!

joeroscia wrote:
This didn't help....multiple folders.  Don't know what files or folders to select.
Then you did not move iTunes as recommended in the link supplied above.
Perhaps there is something here by turingtest2 that can assist you...
https://discussions.apple.com/message/21374537#21374537

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