What do folks do for OFF SITE backups?

We are a small company with 15 employees.
But we have about 40 PC's due to instruments and test equipment.
The Domain Controller is a new 2TB RAID 6 2012 R2 box with Exchange 2013, a couple VM's, and a half a dozen databases.
It's currently at 0.5TB but it could grow to 1TB in a year.
I have used SCSI automated tape drive systems with 8 800GB Tapes.
But they are extremely slow and seem to break every few years.
We have 75/35 Mbs ISP (FIOS).
There are days we could generate 50GB in a day, but not that often.
I'd love a cloud based solution but I can't see how it would possibly work.
Partly because what I would like the "offsite" to be a bare metal "image" of the system.
So I'd ideally I want the Windows Server Backup itself "mirrored" offsite.
But to any tool, I think the "difference" would look like a FULL every night.
The only way would be a backup that understands the differences on the server itself.
Given the complexity of 2012 R2, AD, Exchange, Hyper-V, SQL Server, I'm not sure which 3rd parties could guarantee a successful image restore from a Cloud based incremental.
I'm confident in Windows Backup Server and companies like Backup Exec. But I don't think there is anyway to use those directly to a cloud.
I could run a box at home to mirror too. But that isn't the problem.
We would be willing to upgrade bandwidth but it's the upload speed that's a killer. And even $370.00/month only gets you 100mbs upload.
Bringing hard drives home seems clumsy and error prone.
So what are folks using?

With the amount of data you're talking about I suspect your biggest is likely to be the connectivity to any offsite location, since getting a potential 50GB of new data uploaded is going to take a while.
One possibility which is what we do is to use two installations of MS Data Protection Manager (DPM), which IMHO is way better than Backup Exec these days. You can still backup to tape if required, but we go with backing up to disk instead since it's
a lot faster. You can also backup to both, eg regular backups to disk, and then periodically backup to tape as well.
Have one DPM server onsite which handles the backups each night as normal. Then have the second DPM server at another location, with obvious access into your network. Configure the second DPM server to take replica backups from the first DPM server, which
then give you an offsite copy of your data.
The main benefits are that the local backup can easily complete the nightly backup within the timeframe each day, backing up the data while the server isn't being used at night. Then the second DPM server can grab that data at its leisure, and potentially
if you put in additional comms to handle the backups, it then wouldn't matter at all if the backup transfer continued to run throughout the day, since it would only be putting load on the local DPM server and the connectivity, not your local server. And of
course DPM completely understands things like AD, Exchange etc, so there's no issue there.
Thanks for the comments but how is that much different than the main onsite backup being Windows Server Backup and perhaps the remote site being Windows Server Backup (or any "File based" folder sync tool).
Wouldn't they all have they all have same problem and "see" the primary backup as a large change and try to sync it?
Perhaps if the primary backup was a "mirror" and then a differences of that could go offsite?
Is DPM designed to handle that sort of thing that it won't see the primary backup as large change each night and try to sync too much?

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