What do these applications have in common? Why won't they launch?

Not entirely sure why this has happened now, though think it may be something to do with an Adobe Reader update that only partially installed a few days back, however, virtually all of the applications on my machine will no longer launch, with the exception of Firefox (fortunately), Parallels Desktop and Microsoft Office.
Trying to launch the following applications results in their icon bouncing in the dock a couple of times and then quitting, with no error message (with the exception of adobe suite, which tells me "it's unexpectadly quit"):
Mail
Safari
Skype
Adium
Spotify
iTunes
iDVD
iMovie
SketchUp
Adobe Applications - Photoshop, Illustrator, Dreamweaver and Flash CS3
What is it about the above programs that's not allowing them to work, when Firefox seems to work fine?!
If anyone knows what the problem is, or has any ideas, I would be extremely grateful!
Tom

[kmosx: Apps unexpectedly quit|http://discussions.apple.com/thread.jspa?messageID=607542&#607542]
[XLab FAQ:Applications Unexpectedly Quit|http://www.thexlab.com/faqs/multipleappsquit.html]

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