What is best fragmentation software?

My MacBook Pro with 2Gs RAM and 160G HD has been running very slow, particularly if I have several Safari windows open. I have 37G space available on my 160G HD. In addition to dumping excess files to free up more space on my HD, would a de-fragmentation software program help?

It could mess things up even worse.
You likely have other issues, 37GB of free space on 160GB  is considerable, about 24% which is about when it starts slowing down. So you could remove some files to a external drive that your not using, or may decide to upgrade to a 7,200 RPM drive and more RAM to max out your machines performance.
Lets try something first, you might not have to resort to a full backup, Zero Erase and fresh install of OS X, but that certianly would do the trick much safer than a defragmentation software.
This is going to check out the drive, clean somethings out and perhaps reveal some other issues if they exist or not.
Download the free OnyX and run All the initial checks, maintenance and finally cleaning steps and reboot at the end (you can cancel the in between reboots)
http://www.macupdate.com/app/mac/11582/onyx
You need to download your OS X verison to match. Make sure to enable "all accounts" in OnyX preferences.
Also if it gives any warning, quit and backup your files off the machine as soon as possible and report back here.
Machine may act a bit slower upon reboot, then it should scream, I think you may have a corrupt Safari cache file.

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