What is "run pregrade script for apple devices"?

What  is  "Run pregade script for Apple Device mean. I am tryong to down load Itunes 10.5 on my 2005 Mac. What is the problem?

Are you sure that's how the error message is phrased? Are you sure it doesn't actually say "run preupgrade script for Apple Mobile Device Support"? (note in particular the difference between "preupgrade" and "pregrade" as you have phrased it)
If it really does instead say "preupgrade", not "pregrade", here are a couple of threads with suggestions:
https://discussions.apple.com/thread/3373568?start=0&tstart=0
https://discussions.apple.com/thread/2515630?start=0&tstart=0
If those don't help, this support article may:
http://support.apple.com/kb/HT1747
Regards.

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