What is the main cause of this?

Adobe Illustrator CS2 (not responding)
In the force quit menu? It's not just Illustrator but virtually every program, I just happen to be in Illustrator 80% of the day. The machine is doing it constantly, even after a total wipe of the drive and fresh installation of the OS.
I just get the spinning wheel that lasts forever until I force quit the app. then there's always a (not responding) next to it.
By the way, I'm on an older Quicksilver not the machine in my sig.
Thanks.

it has 1.5 GB RAM and about 250GB free on on startup HD along with another HD of 300GB and then a thrid HD of 20GB.
I'm just trying to figure out what, in general, the (not responding) is usually caused by? Bad RAM, processor, HD?
Again, it was doing this so bad that we decided to just give up and wipe the drive clean and fresh install.

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