What to do after MacPro hangs

Hi,
I'm getting frequent (1 per week) hangs on my MacPro 2.8GHz Octo. This has just started happening in the last month, previously the machine has been perfect - superb even. It's got an 8800 with 10Gb RAM, always update the OS (currently 10.5.4). What happens is the screen just freezes, and the keyboard and mouse don't appear to repond.
My question is what do I do in order to work out what's happening and try and solve the problem?
To date I have tried plugging in different keyboards (no result), ssh'ing in from another machine - I can do this but I don't really know what to do via top to see what the issue is, other than it looks OK (84% idle). However if I issue reboot or shutdown -h now I get 'shutdown: WARNING: couldn't lock kext manager for reboot: (ipc/send) invalid destination port' - see below from dump of ssh issued shutdown command:
Shutdown NOW!
* FINAL System shutdown message from [email protected] *
System going down IMMEDIATELY
shutdown: WARNING: couldn't lock kext manager for reboot: (ipc/send) invalid destination port
System shutdown time has arrived
... and nothing happens.
The only thing I can do is hold the power button on the front until it reboots. I've run disk utility on reboot but it never finds any issues.
Any help would be greatly appreciated,
many thanks,
ROg.

When it freezes, you need to boot from some other drive, emergency partition only need be 20GB.
I delete the cache folders (not in home though) as well as extensions.mkext. Turn off journaling, run Disk Warrior, and when "Okay" do a Safe Boot.
But you also want a bootable backup clone probably along with possibly TimeMachine.
Don't rely on Disk Utility Verify from same drive, or did you boot from another drive to run? my experience is DU not finding IS a problem, it doesn't do as good a job, and hasn't but Alosft and MicroMat out of business. And you can't ask it to scan for weak or bad sectors and try to map out. You also don't get the power of Windows's sfc /scannow (system file checker) that can find corrupt and damaged files.
And that is just to deal with side effects.
The cause is as you tried, often USB cables and devices, 'noise' or something.
Use SuperDuper to clone your drive. See how that works. Or do a fresh install and then later import your home account, or create a new test account to rule out any problem there.
This just has to be the week - I am seeing a couple similar reports every day.

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