What to do if your keyboard and mouse are not responding

What do I do if I were just on my computer and suddenly my keyboard and mouse quit working?  I had a few windows open and I was currently scrolling when it froze.  I forced the device to shut down and when it booted back up, the bluetoothe setup assistant popped up asking to plug in my keyboard.  All my previous windows also opened back up, but still no use of mouse or keyboard.

Could be interference, batteries are going dead or something else.
Keep a wired keyboard and mouse around, in fact one with a nice 3-4 foot cord.
I buy mine from donation places where businesses dump their old rock solid clicky clack USB PC keyboards that are build like a tank, I abuse them too all the time. Drop them, throw them around the room even.
This one I've got, it's over 3 years old and still is rock solid.  Only $4 each.
Rare to get a good used mouse though, really have to buy the newer optical ones now anyway, unless one likes cleaning rollers and the ball.
You need a wired keyboard to execute the boot key commands.
https://discussions.apple.com/community/notebooks/macbook_pro?view=documents

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