What would cause my corded mouse to stop working?

Mid 2010 Mac Pro running OSX 10.6.8.  Was checking e-mail this a.m. and suddenly lost all mouse connection.  Tried different USB ports, and different corded mouse as well as wireless mouse.  Any thoughts as to the cause?  FYI I checked the mouse on a PC at home and it works fine.  Thanks!

At 4 years the PRAM battery starts dying, causing all sorts of peripherals to start to misbehave.

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