When deleting a message in the in box, I get the message "Thunderbird is not responding".

The message is eventually deleted, but it takes a long time for that to happen. This condition just began within the last few days.

"What exactly is "anti-virus s/w"?"
Your anti-virus software, i.e. Bit Defender in your case.
Try to start *Windows* in safe mode with networking enabled.
- Win8 http://windows.microsoft.com/en-US/windows-8/windows-startup-settings-including-safe-mode
- Win7 http://windows.microsoft.com/en-US/windows7/Start-your-computer-in-safe-mode
- XP http://www.microsoft.com/resources/documentation/windows/xp/all/proddocs/en-us/boot_failsafe.mspx
Still in Windows safe mode, start Thunderbird in safe mode.
- https://support.mozilla.org/en-US/kb/safe-mode
Does the problem go away?

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