When I click the Safari app to open it, I keep getting this popup and I cannot close it without force quitting. I also cannot use Safari at all because this keeps poping up what do I do?

I will get this popup and when I try to quit it, it will show another popup called MacKeeper.  I always get this ad however I have never downloaded. I am unable to use Safari because of this issue. I have tried restarting and shutting down my computer, but when I try and reopen Safari, I will get the same message and Mackeeper popup. Please help.    It's like these popup ads have taken over my Safari.  I have run multiple scans on my computer and it says no malware detected and no viruses.                                               

Launch Safari with the Shift key held down. If that doesn’t work, disconnect your computer from the Internet and try again.
Those popups are being opened directly from the web and not by any malware installed on the machine.
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