When I plugged in to iTunes to sync, error OxE8000065 came up.  Any ideas?

My iPad is now non-functional, since the above error notice, with a rotating 'apple' and unable to shut down.  I tried shutting down laptop and unplugging iPad - then rebooting and reconnecting to the USB.  Still no change :>{{  Any help would be gratefully received!

You could try a reset first : press and hold both the sleep and home buttons for about 10 to 15 seconds (ignore the red slider if it appears), after which the Apple logo should appear - you won't lose any content, it's the iPad equivalent of a reboot
Otherwise see if this page helps : http://support.apple.com/kb/TS3221

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