When I try to open a file with TextEdit, I get the spinning beachball and the file takes almost a minute to open.

When I try to open a file with TextEdit, I get the spinning beachball and the file takes almost a minute to open. When I just start TextEdit everything is fine. Also when I log on with another account TextEdit works like a charm, even when opening an existing file.
What I have done so far:
checked permissions in Disk Utility
validated all fonts
deleted all canon printer drivers
deleted all preferences
Nothing has helped. Mail shows the same behavior as TextEdit. What else can I do? Any help would be greatly appreciated.

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drwxr-xr-x  3 admin  staff  -    102 29 Jan 11:19 Library/Caches/com.apple.FontBook
drwxr-xr-x  3 admin  staff  -    102 29 Jan 11:54 Library/Caches/com.apple.KeyboardSetupAssistant
drwxr-xr-x  3 admin  staff  -    102  2 Feb 07:41 Library/Caches/com.apple.PubSubAgent
drwxr-xr-x  3 admin  staff  -    102  2 Feb 07:56 Library/Caches/com.apple.QuickLookDaemon
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drwxr-xr-x  3 admin  staff  -    102 29 Jan 11:15 Library/Caches/com.apple.systemuiserver

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