When I try to open any applications on my Macbook Pro (including finder) the cursor just spins and nothing happens.

It loads as if nothing were wrong, but when I try to click on any program, the cursor just spins and spins. Even when I click the Apple in the upper left corner nothing happens. The cursor just spins. When I hit the keys for force quit, nothing happens. Nothing will open.
I've loaded it in Safe mode, verified the disk (it was okay), and verified and repaired permissions and I am still having issues. When I load in Safe mode, all applications work just fine. I've deleted all contents of my downloads folder (before my computer messed up, the last thing downloaded on my computer was a word document from my friend's email that she'd opened on previous computers with no issue). I don't know what else to do. I have Windows loaded on my Mac and can log-in the Windows side with no problems (that's how I've been using my computer since my Mac side has stopped working).
I'm running version 10.6.8.
Any help would be appreciated!

Select Help ▹ Installed Plug-ins from the Safari menu bar. Besides the following, what plugins are listed?
iPhotoPhotocast
Java
QuickTime
Shockwave Flash
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When I try to open any applications on my Macbook Pro (including finder) the cursor just spins and nothing happens.

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