When itunes is installed missing file -45075 appears, any suggestions

When itunes is installed missing file -45075 appears, any suggestions

Me too.
I have looked at 2-3 other posts, and they still fail to resolve this.
I have reinstalled iTunes; I have repaired every other Apple component and ......
Same message every time. 
I am running fully updated Windows 8 (not 8.1 yet though)
Looking at the number of posts in this discussion group, it does appear to be something that Apple could take a more proactive lead on.  Either a more meaningful error message, or ideally a fully loaded iTunes installation.
COME ON GUYS - help us out here.
If it wasn't that I NEED iTunes to manage and backup my phone, I'd uninstall the %^$*&^ lot.   That said, my 4G upgrade to the iPhone 5S is now in serious doubt ... maybe a time for a complete change.

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