When making changes to the I/O buffer size( motu-pci 424) it takes an abnormal length of time for the changes to take affect any ideas?

when making changes to the I/O buffer size( motu-pci 424) it takes an abnormal length of time for the changes to take affect any ideas?

A fully loaded one( keep in mind I have had fully loaded projects in the past, and it did not take this long) this was noticed after installing LP8, also major latencey even at 64 buffer size

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