When opening PDF files in CS6 they show inverted as default?

Yes (Command I) is a quick fix to this issue but wondering why the default is set as invert?

That file is damaged somehow.  Perhaps during transport.
No other PDF file shows these anomalies on my machine, just yours. 
• Double-clicking on it on the Desktop generates this error message:
• Control-Clicking on the Mac and selecting Open with Photoshop CS6, Photoshop 13.0.5 opens a 2500x1048 pixel image in inverted color mode just like you describe.
• Control-Clicking on the Mac and selecting Open with Acrobat Professional 8.3.1 opens an image with positive colors and the following properties:
• Control-Clicking on the Mac and selecting Open with Preview:
• Opening the image in the Dropbox on the web in the Firefox 23.0 web browser, opens up a positive color image, which when dragged to the Desktop generates a 2500 pixels by 1048 pixels JPEG file which Photoshop opens normally:
The Acrobat error message (first screen shot) may be a clue.

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